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Item No.
32212
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Product Description
ProZinc® (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. PROZINC is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus. If your cat or dog has been diagnosed with diabetes mellitus, you understand the challenges associated with regulating blood glucose and controlling clinical signs. With its appropriate duration of action in each species, PROZINC will provide glycemic control and help improve the quality of life of your cat or dog. PROZINC works by helping your pet break down blood sugar – glucose. Cells typically use insulin to break down glucose, but cats and dogs with diabetes mellitus don’t produce enough insulin, and this causes glucose to build up in their blood and leads to health problems. PROZINC boosts their blood insulin levels, allowing them to break down that glucose and avoid the health problems. PROZINC should only be administered to the cat or dog for whom it was prescribed, and at the dosage and frequency for which it was prescribed. If you have any questions or concerns about the product or about diabetes mellitus, talk to your veterinarian. PROZINC requires refrigeration,² as well as the use of U-40 syringes,² which are sold separately.
What is ProZinc Insulin for Dogs and Cats, 10 ml Vial?
ProZinc® (protamine zinc recombinant human insulin) is an injectable insulin for cats and insulin for dogs. PROZINC is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) and clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus.¹,²
Who is ProZinc Insulin for Dogs and Cats, 10 ml Vial for?
Dogs and Cats
Why use ProZinc Insulin for Dogs and Cats, 10 ml Vial?
FDA-approved for the use in cats and dogs diagnosed with diabetes mellitus. Reduces hyperglycemia and hyperglycemia-associated clinical signs in both cats and dogs with diabetes mellitus. PROZINC must be administered with U-40 syringes² (sold separately). Always follow your veterinarian's directions regarding dosage amount, and when to administer PROZINC.
How does ProZinc Insulin for Dogs and Cats, 10 ml Vial work?
Its stimulates carbohydrate metabolism in heart, bone, and fat tissue
Manufacturer:
Boehringer Ingelheim
Active Ingredients(s):
protamine zinc recombinant human insulin
How is ProZinc Insulin for Dogs and Cats, 10 ml Vial sold?
ProZinc® (Protamine zinc recombinant human insulin) is available as ProZinc 40 units per mL, 10 mL vial.
THIS PRODUCT IS LIMITED TO 1 PER CUSTOMER.
What are the side effects of ProZinc Insulin for Dogs and Cats, 10 ml Vial?
Potential unwanted or dangerous side effects of this product can include: Hypoglycemia (most prevalent). Insulin antagonism/resistance. Fast onset insulin metabolism. Insulin-caused hyperglycemia (Somogyi Effect). Local or systemic responses. Potential indicators of negative reactions to this product include: Weakness, Depression, Fluctuations in behavior, Muscle quivers, Anxiety, Seizures (in serious instances of hypoglycemia). Please call your veterinarian and refer to prescribing information.
What special precautions are there?
PROZINC is for use in cats and dogs only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and to prevent associated complications. Overdose can result in profound hypoglycemia and death. The most common adverse reactions were lethargy, anorexia, hypoglycemia, vomiting, seizures, shaking (dogs only), diarrhea, and ataxia. Many of the adverse reactions, such as lethargy, seizures, shaking (dogs only), and ataxia, are associated with hypoglycemia. The safety and effectiveness of PROZINC in puppies, kittens, or breeding, pregnant, and lactating animals has not been evaluated. PROZINC is contraindicated during episodes of hypoglycemia and in animals sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC.
What to do if overdose?
Contact your nearest emergency animal hospital.
How can I store ProZinc Insulin for Dogs and Cats, 10 ml Vial?
Store in an upright position under refrigeration at 36-46°F (2-8°C). Do not freeze. Protect from light.
Helpful Tips:
It is best to give your cat's PROZINC injections at feeding time or just afterward. It is also best to give the injections at the same time every day, because it will help your cat maintain the most stable blood glucose levels. This will be easier to do if you stick closely to your feeding schedule.
When you give your cat a PROZINC injection, make sure you use the correct type of syringe. PROZINC is a U-40 insulin, meaning that there are 40 units of insulin per milliliter (ml) of product. That is why PROZINC must be injected with a U-40 syringe. This is very important because using another type of syringe will deliver the wrong dose.
Overview
USE OF A SYRINGE OTHER THAN A U-40 SYRINGE WILL RESULT IN INCORRECT DOSING. FOR SUBCUTANEOUS INJECTION ONLY. DO NOT SHAKE OR AGITATE THE VIAL. PROZINC should be mixed by gently rolling the vial prior to withdrawing each dose from the vial. Once mixed, PROZINC suspension has a white, cloudy appearance. Clumps or visible white particles can form in insulin suspensions: do not use the product if clumps or visible white particles persist after gently rolling the vial. Using a U-40 insulin syringe, the injection should be administered subcutaneously on the back of the neck or on the side of the cat. Always provide the Client Information Sheet with each prescription. The initial recommended PROZINC dose is 0.1 – 0.3 IU insulin/pound of body weight (0.2 – 0.7 IU/kg) every 12 hours. The dose should be given concurrently with or right after a meal. The veterinarian should re-evaluate the cat at appropriate intervals and adjust the dose based on both clinical signs and glucose nadirs until adequate glycemic control has been attained. In the effectiveness field study, glycemic control was considered adequate if the glucose nadir from a 9-hour blood glucose curve was between 80 and 150 mg/dL and clinical signs of hyperglycemia such as polyuria, polydipsia, and weight loss were improved. Further adjustments in the dosage may be necessary with changes in the cat’s diet, body weight, or concomitant medication, or if the cat develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder.
Main Ingredients
Each ml contains:
Recombinant human insulin…. 40 International Units (IU)
Protamine sulfate…………………… 0.466 mg
zinc oxide……………………………… 0.088 mg
glycerin …………………………………… 16.00 mg
dibasic sodium phosphate…….... 3.78 mg
heptahydrate
phenol (added as preservative)..2.50 mg
hydrochloric acid………………………..1.63 mg
water for injection (maximum)..1005 mg
pH is adjusted with hydrochloric acid and/or sodium hydroxide.
